Development,characterization and Solubility Study of Solid Dispersion of Cefpodoxime Proxetil by Solvent Evaporation Method

Cefpodoxime Proxetil (Poorly water soluble drug), when prepared as solid dispersion showed improved solubility and dissolution. So the main purpose of this investigation was to increase the solubility and dissolution rate of Cefpodoxime Proxetil by the preparation of its solid dispersion with urea using solvent evaporation method. Physical mixtures and solid dispersions of Cefpodoxime Proxetil were prepared by using urea as water-soluble carrier in various proportions (1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7 by weight), by employing solvent evaporation method. The drug release prole was studied and it was found that the dissolution rate and the dissolution parameters of the drug from the physical mixture as well as solid dispersion were higher than those of the intact drug. FTIR spectra revealed no chemical incompatibility between drug and urea. Drug-polymer interactions were investigated using differential scanning calorimetry (DSC) and Powder X-Ray Diffraction (PXRD).